Clinical Pharmacology & Therapeutics

1. Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account

   Clinical Pharmacology &Therapeutics, EarlyView.

2. The Drug Titration Paradox Updated and Reinterpreted: With Perfect Titration, Dose and Effect Will Be Uncorrelated

   Clinical Pharmacology &Therapeutics, EarlyView.

3. Oncology Dose Optimization: Tailored Approaches to Different Molecular Classes

   Clinical Pharmacology &Therapeutics, EarlyView.

4. ESR1 Variants and Subcontinental Genomic Ancestry: Insights from the 1000 Genomes Project and Native American Populations

   Clinical Pharmacology &Therapeutics, EarlyView.

5. Innovations and Best Practices for Therapeutic Development in Pediatric Rare Diseases: A Model‐Informed Drug Development Perspective

   Clinical Pharmacology &Therapeutics, EarlyView.

6. Supplementing Single‐Arm Trials with External Control Arms—Evaluation of German Real‐World Data

   Clinical Pharmacology &Therapeutics, EarlyView.

7. Prenatal and Early Childhood Exposure to Antibiotics or Gastric Acid Inhibitors and Increased Risk of Epilepsy: A Nationwide Population‐Based Study

   Clinical Pharmacology &Therapeutics, EarlyView.

8. Clinical Benefit, Trials, and Regulatory Approval of Oncology Indications Under Multiple Expedited Programs for Drug Marketing in China, 2018–2024

   Clinical Pharmacology &Therapeutics, EarlyView.

9. Emergence of Small Nucleic Acids as Drugs in Precision Medicine

   Clinical Pharmacology &Therapeutics, EarlyView.

10. In this Issue

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1157-1158, May 2025.

11. Optimal Drug, Optimal Dose, or Both in the Pharmacological Treatment of Neonatal Opioid Withdrawal Syndrome?

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1182-1184, May 2025.

12. Highlighted Articles

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1162-1163, May 2025.

13. ASCPT News

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1164-1170, May 2025.

14. MRI Provides New Insights Into the Pharmacologic Mechanism of Bisacodyl: A Blueprint for Understanding Intestinal Drug Mechanisms

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1159-1161, May 2025.

15. Issue Information

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1149-1154, May 2025.

16. Correction to “Lenacapavir: Playing the Long Game in the New Era of Antiretrovirals”

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1470-1470, May 2025.

17. Methodological Insights on Biomarker‐Based Patient Selection: A Review of Scientific Advice Procedures at the European Medicines Agency

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1226-1235, May 2025.

18. A 2024 Update on US FDA Implementation of Partial Area Under the Curve Into Bioavailability and Bioequivalence Assessments

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1185-1193, May 2025.

19. The Role and Mechanisms of Aurora Kinases in Kidney Diseases

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1217-1225, May 2025.

20. Characterizing Treatment Effect Heterogeneity Using Real‐World Data

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1209-1216, May 2025.