New England Journal of Medicine - Clinical Medicine

1. Phase 3 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis

   In this randomized trial involving patients with noncystic fibrosis bronchiectasis, the rate of pulmonary exacerbations over a 52-week period was lower with brensocatib (10 mg or 25 mg per day) than with placebo.

2. Southern Tick-Associated Rash Illness

   A 65-year-old man presented with 1-day history of a rash with a bull’s-eye appearance on his left hip. One week earlier, he had removed a tick from his hip after doing yard work near the woods by his home in Tennessee.

3. Pavement Burns

   A 56-year-old man was transferred to a burn center for management of pavement burns on his feet that had occurred during a heat wave.

4. Science behind the Study: Defanging the Neutrophil to Treat Bronchiectasis

   The author describes the scientific foundations of a phase 3 study of brensocatib for the treatment of bronchiectasis.

5. Cutaneous Leishmaniasis

   A 3-year-old boy presented with a 6-week history of ulcerated plaques with rolled borders and satellite papules on his left lower leg. He had recently immigrated from Venezuela after a long journey by land with his family.

6. EPSDT — Medicaid’s Mandate for Children and Adolescents

   The Early and Periodic Screening, Diagnostic, and Treatment benefit supports access to various services for Medicaid-covered children. But few clinicians are aware of the extent of its coverage guarantees.

7. Brensocatib in Bronchiectasis — A New Sheriff in Town?

   Bronchiectasis unrelated to cystic fibrosis is the third most common chronic pulmonary disorder after asthma and chronic obstructive pulmonary disease.1 Bronchiectasis has multiple causes and is characterized by recurrent and often chronic productive cough, lower airway infection and inflammation, and irreversible bronchial dilatation.2 Irrespective of the...

8. Case 12-2025: A 56-Year-Old Woman with Sore Throat and Rash

   A 56-year-old woman experiencing homelessness was evaluated at this hospital because of sore throat and a pruritic rash on her face, chest, abdomen, and legs. A diagnosis was made.

9. Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension

   In this trial of the aldosterone synthase inhibitor lorundrostat in participants with uncontrolled hypertension, lorundrostat was associated with greater reductions in blood pressure than placebo.

10. Nutrition in Medicine: Enteral Nutrition in Hospitalized Adults

    This review considers enteral nutrition in the context of disease-related malnutrition, provides evidence for the use of enteral nutrition in hospitalized patients, and discusses practice considerations.

11. Hemiplegic Migraine

    A 46-year-old woman with a history of migraine with visual aura presented with a 3-hour history of headache, as well as weakness and numbness in the right arm.

12. Round Pneumonia

    A 4-year-old girl presented with a 3-day history of fever and dry cough. A chest radiograph showed a large, rounded opacity in the left lower lobe with subtle air bronchograms.

13. Case 11-2025: A 79-Year-Old Woman with Cough and Weight Loss

    A 79-year-old woman was evaluated for cough and weight loss. Chest imaging and thoracentesis findings confirmed the presence of an exudative right pleural effusion. A diagnosis was made.

14. To B or Not to B — the Role of B-Cell Depletion in Lupus Nephritis

    B cells play a key role in the pathogenesis of lupus nephritis, yet in the Lupus Nephritis Assessment with Rituximab (LUNAR) trial, rituximab therapy did not improve clinical outcomes after 1 year of treatment.1 The success of anti-CD19 chimeric antigen receptor T cells in selected patients with refractory...

15. Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion

    In a trial involving patients with ischemic stroke due to medium-vessel occlusion, thrombectomy within 12 hours did not lead to a better functional outcome and lower mortality at 90 days than usual care.

16. Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels

    In this trial involving 543 patients with stroke due to occlusion of medium or distal vessels, endovascular treatment within 24 hours after the onset of symptoms was not effective in improving functional outcome at 90 days.

17. Otitis Media in Young Children

    Acute otitis media occurs almost exclusively after a viral upper respiratory tract infection. Children with mild or moderate symptoms can be treated with antibiotics or closely observed.

18. Postexercise Facilitation of Reflexes in the Lambert–Eaton Myasthenic Syndrome

    A 54-year-old man presented with a 5-month history of weakness. Examination showed proximal muscle weakness and absent patellar reflexes that briefly reappeared after voluntary muscle contraction (shown in a video).

19. Efforts toward Equity: Developing a Primary Care Workforce for Underserved Communities — The UC Davis TEACH Program

    The U.S. shortage of primary care physicians disproportionately affects underserved communities, and the inequities are compounded by the racial and linguistic diversity gaps between patients and doctors.

20. Efforts toward Equity: Ensuring Inclusive, Affirming Care for LGBTQ+ Patients — Scaling Up Cultural Competency Training

    Affirm: The Rush Center for Gender, Sexuality, and Reproductive Health aims to improve access to culturally competent, relevant health care for the LGBTQ+ community throughout the Chicago metropolitan area.