New England Journal of Medicine - Geriatry

1. More Evidence That Viral Infections Can Be a Trigger for Dementia

   Herpesviruses and SARS-CoV-2 can disrupt brain cell function and cause neuroinflammation.

2. Shingles Vaccine Apparently Lowers Risk for Dementia

   In a “natural experiment,” researchers compared dementia diagnoses among people who did or did not receive herpes zoster vaccination.

3. Bleeding During Anticoagulation for Atrial Fibrillation and Subsequent Malignancy

   Bleeding was associated strongly with cancer diagnoses at the site of bleeding.

4. When Does Empirical Treatment Fail for Uncomplicated UTIs?

   Be worried about patients in whom treatment has failed previously.

5. Does Escitalopram Prevent Alzheimer-Related Agitation?

   A randomized trial failed to replicate positive findings seen with a related drug, citalopram, and showed the same troubling side effects.

6. What Happens to Cognition Before and After a Transient Ischemic Attack or Stroke?

   Both TIA and stroke led to cognitive declines in a large, longitudinal epidemiological cohort.

7. CRP-Stratified Steroid Prescribing for Severe CAP

   C-reactive protein level might distinguish which patients hospitalized with community-acquired pneumonia require systemic corticosteroids.

8. Do NSAIDs Cause Marginal Ulcers in Patients After Gastrojejunostomy?

   Findings from a large cohort suggest the answer is yes.

9. To Operate or Not to Operate (on Humeral Shaft Fractures): That Is the Question

   This randomized trial showed early functional advantages for surgery over bracing, but long-term results were similar.

10. Cardiovascular Outcomes with Oral Semaglutide in High-Risk Patients with Type 2 Diabetes

    The oral version lowered the incidence of adverse CV events by 2 percentage points during 4 years.