FARMACI, INQUINAMENTO AMBIENTALE ED EFFETTI SULLA SALUTE
Inquinamento ambientale dei farmacidrugs and environmental pollution: Latest results from PubMed
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Advances in valorization of Camellia oleifera Abel. Seed cake: A review on the bioactive components, health benefits, extraction methods, and potential food applications
Camellia oleifera Abel. Seed cake (CSC) is a by-product of camellia oil processing. Owing to the lack of effective utilization, CSC are typically discarded or used as animal feed, fertilizer, or cleaning agents, which limits their full potential and causes environmental pollution. However, the high levels of bioactive compounds in CSC indicate their significant potential in the food industry. The primary bioactive components of CSC are proteins, polysaccharides, polyphenols, and saponins. Both... -
Current applications of benchtop FT-NMR in food science: From quality control to adulteration detection
The introduction of benchtop FT-NMR spectrometers in recent years represents a remarkable innovation in various fields, including the food sector. Modern benchtop FT-NMR spectrometers are low-field instruments, with a magnetic field ranging from 1 T to 2.35 T (¹H resonance frequency from 43 MHz to 100 MHz), characterized by compact design, ease of use, and low maintenance costs. As in the case of high-field NMR instruments, benchtop NMR spectra (obtained by Fourier transformation) contain... -
The Impact of Microplastics in Food and Drugs on Human Health: A Review of the MENA Region
Microplastics (MPs), defined as plastic particles smaller than 5 mm, have emerged as a global environmental and public health crisis, infiltrating air, water, soil, and food systems worldwide. MPs originate from the breakdown of larger plastic debris, single-use plastics, and industrial processes, entering food. Emerging evidence underscores the ability of MPs to cross biological barriers, including the blood-brain barrier, triggering neuroinflammatory responses and contributing to... -
A systematic review and meta-analysis of antibiotic resistance of foodborne pathogenic bacteria
Antimicrobial drugs are used to treat bacterial pathogens that cause infections in humans and animals. Despite their importance, antimicrobial drugs exhibit inefficiency in treating infections if used irrationally without adherence to standard guidelines. Currently there is a lack of review literatures concerning antimicrobial resistance status in the southern sub Saharan African countries, hence the study is designed for and provides valuable insights into the status and comparison of... -
Current issues of regulation of contaminants in food
In the Russian Federation, ensuring food security is one of the main tasks of state policy, which is reflected in the national Food Security Doctrine, which declares the need not only to control products for compliance with the mandatory requirements of the technical regulations of the Eurasian Economic Union, but also to harmonize food quality and safety standards with international ones. The purpose of the work was to identify priorities for the development or revision of characteristics and... -
Flavor effect, application status, and research trend of umami peptides based on microbial fermentation in food
Umami peptides are important non-volatile compounds produced by protein degradation, contributing to food umami flavor and enhancing product quality. Microbial fermentation promotes the production of taste peptides, including umami peptides, which act as key flavor substances and precursors. Microbial-derived umami peptides are cost-effective, easy to produce, and a major source of umami peptide production. Although microbial fermentation of umami peptides has been extensively studied in... -
Pharmaceutical waste management through microbial bioremediation
Pharmaceuticals play a significant role in enhancing the quality of life. However, pharmaceutical products (PPs) manufacturing presents challenges, particularly in terms of waste generated, posing a risk to the ecosystem. Existing physical and chemical remediation methods are expensive and are not directly applicable for pharmaceutical remediation. Bioremediation using various microbial consortia has the potential to become a cost-effective solution when applied optimally. This review highlights... -
Nutraceutical potential of Mediterranean agri-food waste and wild plants: Green extraction and bioactive characterization
The agricultural waste and wild plants of the Mediterranean region offer significant nutraceutical potential, rich in bioactive compounds such as phenolics, carotenoids, lipids and volatile organic compounds. These compounds exhibit health-promoting properties, including antioxidant, neuroprotective and anti-inflammatory effects. Advanced analytical techniques such as HPLC, GC-MS and NMR are essential for the accurate chemical characterization of these bioactives. Green extraction methods,... -
Research Progress in Epoxidation of Light Small-Molecule Olefins
Light olefins, as important bulk raw materials in the petrochemical industry, play an irreplaceable role in the development of the manufacturing industry and the economy. The epoxides of light olefins are important intermediates for the synthesis of polymers, drugs, and fine chemicals, and their green, efficient, and safe synthesis has attracted much attention. This review focuses on the research progress of light olefin epoxidation and elucidates traditional epoxidation methods, such as the... -
Research advances in non-immobilized aptamer screening techniques for small-molecule targets
Aptamers obtained through systematic evolution of ligands by exponential enrichment (SELEX) techniques are single stranded deoxyribonucleic acid (ssDNA) or RNA molecules capable of specifically recognizing target molecules. Such aptamers are easily chemically synthesized and modified, highly thermally stable, and are low toxicity and low immunogenicity. Aptamers that target small molecules have broad applications prospects for the development of new drugs, treating tumors, diagnosing diseases,... -
Recent Advances in Metabolomic Research Within Food Mycology
In food science, fungi demonstrate a paradoxical role: some species contribute positively by improving food's flavor, aroma, and texture, while others undermine food safety and quality, leading to spoilage or contamination through the production of harmful mycotoxins. When fungi colonize food materials, they produce distinct chemical profiles consisting of both primary and secondary metabolites. Metabolomics, a field dedicated to the analysis of small molecular compounds within biological... -
Immunotoxicological disruption of pregnancy as a new research area in immunotoxicology
Immune mechanisms associated with normal pregnancy have only been being substantively investigated since the early 1990s. In parallel with the progress in that area of research, in the past few years it has become increasingly clear that several xenobiotics - including a variety of environmental chemicals, pharmaceuticals, and metals are considered to be both generally immunotoxic and specifically able to affect pregnancy. Among these, there is intense interest regarding potential effects from... -
Global, regional, and national burden of household air pollution, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
BACKGROUND: Despite a substantial reduction in the use of solid fuels for cooking worldwide, exposure to household air pollution (HAP) remains a leading global risk factor, contributing considerably to the burden of disease. We present a comprehensive analysis of spatial patterns and temporal trends in exposure and attributable disease from 1990 to 2021, featuring substantial methodological updates compared with previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors... -
A comprehensive review on the treatment of pharmaceutically active compounds using moving bed biofilm reactor: A systematic meta-analysis coupled with meta-neural approach
Pharmaceutically active compounds (PhACs) in wastewater pose challenges to cleaner environment due to their recalcitrance and toxicity, restricting the use of conventional treatment methods. On the other hand, advanced oxidation processes face technical complexity and financial constraints, which also discourage their applicability especially in large scale treatment system. Moving Bed Biofilm Reactor (MBBR) as an advanced biological treatment system has shown remarkable efficacy and... -
Neurobehavioral effects of low dose exposure to chemical mixtures: a review
Neurological disorders have become the leading cause of disease and disability worldwide, with 80% of these conditions being recorded in low- and middle-income countries. Scientific evidence has increasingly associated these disorders with exposure to xenobiotics, such as pesticides, heavy metals and endocrine-disrupting chemicals (EDCs). Recent studies have focused on the consequences of exposure to chemical mixtures and their potential neurotoxic effects. As reported, such exposures can... -
Pharmacotherapeutic Strategies for Fine Particulate Matter-Induced Lung and Cardiovascular Damage: Marketed Drugs, Traditional Chinese Medicine, and Biological Agents
Fine particulate matter (PM(2.5)), defined as airborne particles with a diameter of ≤ 2.5 μm, represents a major constituent of air pollution and has been globally implicated in exacerbating public health burdens by elevating morbidity and mortality rates associated with respiratory and cardiovascular diseases (CVDs). Adverse health effects of PM(2.5) exposure manifest across diverse susceptibility profiles and durations of exposure, spanning both acute and chronic timelines. While prior reviews... -
Advancing fungal biodegradation of nonsteroidal anti-inflammatory drugs - challenges and future perspectives
Environmental pollution poses serious threats to ecosystems, human health, and overall quality of life. Among the most concerning pollutants are emerging contaminants like nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used in human and veterinary medicine. These drugs and their metabolites are excreted into wastewater systems, where existing treatment methods often fail to eliminate them fully. Due to their persistence in aquatic environments, NSAIDs accumulate, necessitating... -
Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review
The etiology of Parkinson's disease (PD) is complex and multifactorial, depending on interactions involving environmental/lifestyle and genetic factors. The genetic aspects of the disease are becoming well characterized, while the environmental factors still need further investigation. In the present narrative review, we have described the most concrete evidence of associations between environmental factors and the risk of developing PD. Physical activity, healthy dietary patterns, smoking, and... -
Pollution by antimicrobials and antibiotic resistance genes in East Africa: Occurrence, sources, and potential environmental implications
The escalating burden of antimicrobial pollution in East Africa poses severe threats to public health, environmental integrity, and economic stability. Environmental compartments such as soil and water serve as reservoirs for these pollutants such as antimicrobials and antibiotic resistance genes, creating selective pressure that accelerates the emergence of antimicrobial resistance (AMR). These dynamic fosters the proliferation of multidrug-resistant pathogens, or "superbugs," complicating... -
A systematic review/meta-analysis of xenobiotics in apple products highlights lack of compliance with European Food Safety Authority Regulation
Apples and their derivatives are among the most widely consumed fruit products in the world and iconic examples of food-safety issues. By using a systematic search in the PubMed, Web of Science, and Embase databases, we extracted 1374 publications on pesticides, mycotoxins, and heavy metal contents in apple products, which represented 44%, 48%, and 26% of publications on fruit, respectively. We selected 90 articles in which we were able to assess compliance with the European Food Safety... -
Metabolic insights of lactic acid bacteria in reducing off-flavors and antinutrients in plant-based fermented dairy alternatives
Multiple sensorial, technological, and nutritional challenges must be overcome when developing plant-based fermented dairy alternatives (PBFDA) to mimic their dairy counterparts. The elimination of plant-derived off-flavors (green, earthy, bitter, astringent) and the degradation of antinutrients are crucial quality factors highlighted by the industry for their effect on consumer acceptance. The adaptation of plant-derived lactic acid bacteria (LAB) species into plant niches is relevant when... -
Radiation-induced lung injury: from mechanism to prognosis and drug therapy
Radiation induced lung injury, known as the main complication of thoracic radiation, remains to be a major resistance to tumor treatment. Based on the recent studies on radiation-induced lung injury, this review collated the possible mechanisms at the level of target cells and key pathways, corresponding prognostic models including predictors, patient size, number of centers, radiotherapy technology, construction methods and accuracy, and pharmacotherapy including drugs, targets, therapeutic... -
The cutting edge of surveillance: Exploring high-resolution mass spectrometry in wastewater-based epidemiology for monitoring forensic samples
Criminal activity has always been detected through forensic evidence. However, the potential for using such evidence to stop crimes in their tracks or slow them down has not yet been completely realized. There is a lot of potential for assessing trace quantities of chemicals in wastewater systems to provide effective forensic information. Wastewater-based epidemiology (WBE) has emerged in the last decades as a crucial epidemiological information source for collecting data on community-wide... -
Application Progress of Electron Beam Radiation in Adsorption Functional Materials Preparation
To solve the problems of water and air pollution, adsorption functional materials (ASFMs) have been extensively investigated and applied. Among the preparation methods of ASFM, electron beam radiation (EBR) has attracted much attention for its high efficiency, environmental friendliness, and wide applicability. Based on the introduction of the application of EBR technology, the EBR preparation of ASFM is summarized by grafting and cross-linking. Secondly, the application of corresponding ASFM... -
Cytokine therapy of acute radiation syndrome
Radiological accidents/incidents are common with nearly 400 reported since 1944 exposing about 3000 people to substantial doses of ionizing radiations with 127 deaths. Damage to hematopoietic stem and progenitor cells with resulting bone marrow failure is a common consequence of exposure to whole body acute high-dose and -dose-rate ionizing radiations and is termed hematopoietic-acute radiation syndrome, or H-ARS. Therapy of H-ARS includes transfusions, anti-bacterial and -viral drugs,... -
Novel Approach Methodologies in Modeling Complex Bioaerosol Exposure in Asthma and Allergic Rhinitis Under Climate Change
The undeniable impact of climate change and air pollution on respiratory health has led to increasing cases of asthma, allergic rhinitis and other chronic non-communicable immune-mediated upper and lower airway diseases. Natural bioaerosols, such as pollen and fungi, are essential atmospheric components undergoing significant structural and functional changes due to industrial pollution and atmospheric warming. Pollutants like particulate matter(PMx), polycyclic aromatic hydrocarbons(PAHs),... -
Glucocorticoids as emerging pollutants in surface water: A systematic review on their global occurrence and distribution
Glucocorticoids (GCs) are synthetic drugs widely used for treating several diseases with inflammatory pathophysiology. In general, 1-20% of the concentration of GCs initially administered is eliminated unchanged in the urine while still in its active form, and therefore, fractions of GCs are constantly released in effluents. Currently, water treatment plants do not have sufficiently effective technologies to remove these substances completely, favoring the presence of these emerging pollutants... -
Deep eutectic solvents in food contaminants detection: Characteristics, interaction mechanism and application advances from extracting to other roles
Food safety is crucial for public health, yet it faces growing threats from environmental and anthropogenic pollutants. Deep eutectic solvents (DESs) have emerged as green and efficient alternative solvents for detecting trace pollutants. This review highlights the characteristics of DESs, their mechanisms for extracting target analytes and applications in food analysis. Subsequently, the challenges faced by DESs in the detection of food samples and future development trends are further... -
Home Environment as a Therapeutic Target for Prevention and Treatment of Chronic Diseases: Delivering Restorative Living Spaces, Patient Education and Self-Care by Bridging Biophilic Design, E-Commerce and Digital Health Technologies
A high prevalence of chronic diseases exposes diverse healthcare pain points due to the limited effectiveness of pharmaceutical drugs and biologics, sedentary lifestyles, insufficient health literacy, chronic stress, unsatisfactory patient experience, environmental pollution and competition with commercial determinants of health. To improve patient care and long-term outcomes, the impact of the home environment is overlooked and underutilized by healthcare. This cross-disciplinary work describes... -
The Toxic Effects of Environmental Domoic Acid Exposure on Humans and Marine Wildlife
Biotoxins produced by harmful algal blooms (HABs) are a substantial global threat to ocean and human health. Domoic acid (DA) is one such biotoxin whose negative impacts are forecasted to increase with climate change and coastal development. This manuscript serves as a review of DA toxicosis after environmental exposure in humans and wildlife, including an introduction to HAB toxins, the history of DA toxicosis, DA production, toxicokinetic properties of DA, susceptibility, clinical signs, DA... -
Role of Epigenetics in Chronic Lung Disease
Epigenetics regulates gene expression and thus cellular processes that underlie the pathogenesis of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Environmental factors (e.g., air pollution, smoking, infections, poverty), but also conditions such as gastroesophageal reflux, induce epigenetic changes long before lung disease is diagnosed. Therefore, epigenetic signatures have the potential to serve as biomarkers that... -
Recent advances in the electrochemiluminescence detection of small molecule drugs
The detection of small molecule drugs is crucial in clinical treatment and environmental protection by facilitating the optimization of therapeutic regimens, preventing adverse drug reactions and monitoring environmental pollution. Electrochemiluminescence (ECL) is widely employed in the detection of small molecule drugs due to its high sensitivity and low background signal. This review highlights advancements from the last five years or so in ECL detection methods based on ECL reactions between... -
Chemical risk assessment in food animals via physiologically based pharmacokinetic modeling - Part I: Veterinary drugs on human food safety assessment
Veterinary drugs and environmental pollutants can enter food animals and remain as residues in food chains threatening human food safety and health. Performing health risk and food safety assessments to derive safety levels of these xenobiotics can protect human health. Physiologically based pharmacokinetic (PBPK) modeling is a mathematical tool to quantitatively describe chemical disposition in humans and animals informing human food safety and health risk assessments. However, few reviews... -
Research progress on the diversity, physiological and functional characteristics of lactic acid bacteria in the Nongxiangxing baijiu microbiome
Nongxiangxing baijiu (NXXB) is one of the main types of Chinese Baijiu. Its unique flavor is formed during fermentation by the combined action of various microorganisms, with lactic acid bacteria (LAB) making a great contribution. Lactate fermentation produces the precursors of key flavor compounds, such as lactic acid, acetic acid, and other flavor compounds, which combine to produce the unique sensory characteristics of NXXB. This review focuses on the diversity of LAB species and their... -
A critical review of COFs-based photocatalysis for environmental remediation
Covalent organic frameworks (COFs) are highly porous crystalline polymers formed through covalent bonding of molecular building blocks. Numerous fabrication strategies have been developed, including solvothermal, ionothermal, microwave, mechanochemical, and sonochemical methods, alongside ligand substitution and post-modification techniques, which allow for precise control over the structures and properties of COFs. The exceptional physicochemical stability, large specific surface area, broad... -
A review on recent progress in polysaccharide/protein hydrogels in winter sports: Classification, synthesis routes, and application
In today's world, emerging materials play prominent roles in competitive sport applications. Among them, hydrogels gained increasing attention in winter sports applications owing to their unique advantages, such as flexibility, conductivity, and adhesion. However, traditional hydrogels prepared by synthetic routes from petroleum materials lose performance at freezing temperatures below zero degrees, limiting their direct use in winter sports. The emergence of natural polymer materials has... -
Recent occurrence of pharmaceuticals in freshwater, emerging treatment technologies, and future considerations: A review
Pharmaceuticals represent an emerging class of pollutants raising significant environmental health concerns, with their presence in freshwater systems linked to adverse aquatic ecosystem impacts and acceleration of antibiotic resistance development. This narrative review examines recent (2019-2024) pharmaceutical occurrences in freshwater globally, analyzes contamination pathways, evaluates compound-specific degradability, and assesses treatment technologies. Analysis revealed significant... -
Pesticides and veterinary pharmaceuticals in neotropical avian carnivores: A scoping review
Organic contaminants have long been known to have negative consequences for wildlife health. For avian carnivores, particular concern surrounds the use of compounds such as pesticides and pharmaceutical drugs, derived from global agricultural and veterinary practices. Previous cases of avian poisoning in North America, Europe and Asia have received great attention, owing to significant declines in avian populations and wider consequences. By contrast, the Neotropics, comprised of Latin America... -
Spent Coffee Grounds as a Source of Chlorogenic Acid
Spent coffee grounds generated from the brewing of coffee cherries are rich in chlorogenic acids that are associated, to a certain extent, with a delay in the development of various chronic diseases and age-related disorders. These natural antioxidants are applied in the pharmaceutical, cosmetic, and food industries. This brief overview describes recently proposed procedures for the extraction and recovery of chlorogenic acids from spent coffee grounds, which is a low-cost and easily accessible... -
The Heterogeneous Multi-Habitat Assay System (HeMHAS): A non-forced ecotoxicology test system to study contamination-driven habitat selection behavior from landscape and stress ecology perspectives
In ecotoxicology, the non-forced exposure approach provides a complementary perspective to traditional ecotoxicity tests by giving the organisms an opportunity to flee to adjacent, less contaminated areas, thus allowing them to escape from any toxic effects. This approach recognizes the chemical heterogeneity among connected habitats with different levels of contamination. The Heterogeneous Multi-Habitat Assay System (HeMHAS) is a non-forced aquatic assay system that allows the free movement of... -
Advances in conducting nanocomposite hydrogels for wearable biomonitoring
Recent advancements in wearable biosensors and bioelectronics have led to innovative designs for personalized health management devices, with biocompatible conducting nanocomposite hydrogels emerging as a promising building block for soft electronics engineering. In this review, we provide a comprehensive framework for advancing biosensors using these engineered nanocomposite hydrogels, highlighting their unique properties such as high electrical conductivity, flexibility, self-healing,... -
Advances in structure designing and function tailoring strategy toward alginate-based hydrogels for efficient water remediation: A review
Alginate (mainly sodium alginate, SA), as a natural polysaccharide material, has been widely applied in water remediation due to its excellent biocompatibility, degradability, and high hydration properties. Alginate hydrogels exhibit high adsorption capacity, effectively removing heavy metal ions, dyes, antibiotics, phosphate ions, and other pollutants from wastewater. This review begins with a description of the chemical structure of sodium alginate and its physicochemical properties, followed... -
Photocatalytic degradation of veterinary antibiotics in wastewaters: A review
The extensive use of veterinary antibiotics worldwide has led to their increasing accumulation in aquatic environments, adversely affecting both ecosystems and human health and leading to the emergence of antibiotic-resistant bacteria. Antibiotic residues enter water bodies primarily through wastewater effluent discharge, agricultural runoff, and improper disposal of pharmaceuticals. Several emerging technologies have been developed in response to the challenge of antibiotic contamination in... -
Biochar for mitigating pharmaceutical pollution in wastewater: A sustainable solution
Pharmaceutical contaminants (PCs), including antibiotics, analgesics, and other medications, pose a growing threat to aquatic ecosystems and human health due to their persistence and bioaccumulation potential. Biochar, a carbonaceous material derived from biomass pyrolysis, has emerged as a sustainable adsorbent for removing PCs from wastewater. Biochar is reported to remove PCs from water with an average range of 58 to 91 %, depending on the nature of feedstock, pyrolysis conditions, and... -
Innovations in cellulose-based hydrogels for enhanced wastewater treatment through adsorption
Cellulose-based hydrogels are versatile and biodegradable materials derived from renewable cellulose sources. These hydrogels possess unique properties, such as high water absorption capacity, tunable mechanical strength and excellent biocompatibility. Their porous structure and functional groups enable effective interactions with contaminants and making them ideal candidates for water purification. In wastewater treatment, cellulose-based hydrogels are widely utilized for adsorbing heavy metals... -
Current scenario of emerging pollutants in farmlands and water reservoirs: Prospects and challenges
Globally, roughly more than 400 million metric tons of plastics are produced annually. Similarly, the pharmaceuticals business is rising exponentially yearly, 5.8 %. It is expected to increase from USD 714 billion to USD 1454 billion by 2029. Beyond their intended uses, these substances are released into the environment as contaminants due to improper usage and management practices. Therefore, pharmaceuticals and microplastics (MPs) are classified as emerging pollutants (EPs), and their... -
Pharmaceutical waste management legislations: Where do ASEAN countries stand in harmonization? A review of regulatory documents
Although healthcare waste management (HCWM) legislations prevail in Association of Southeast Asian Nations (ASEAN), there appears a prominent gap in standalone pharmaceutical waste management (PWM) legislation making harmonization of PWM challenging in the region. This review is aimed to comprehensively overview the PWM-related legislations in ASEAN, comprising of 10 economically rising countries in Southeast Asia. The relevant regulatory documents, that were promulgated till August 31, 2024 and... -
The role of residual (veterinary) antibiotics in chemical exposome analysis: Current progress and future perspectives
Humans are exposed to a complex mixture of environmental and food-related chemicals throughout their lifetime. Exposome research intends to explore the nongenetic, that is, environmental causes of chronic disease and their interactions comprehensively. Residual antibiotics can enter the human body through therapeutics, foods of animal origin, aquatic products, or drinking water. In the last decade, significant levels of residual antibiotics in human urine have been described, demonstrating... -
Inspection of Residual Veterinary Drugs at Tokyo Metropolitan Institute of Public Health: Bioassay and LC-MS/MS Analysis
Veterinary drugs are used worldwide to prevent and treat diseases and promote growth in animals, fisheries, and beekeeping. Despite their effectiveness, the illegal and improper use of these drugs can result in livestock and fishery products, potentially impacting human health by causing allergic reactions, cytotoxicity, and antimicrobial resistance. To mitigate these adverse effects, the Japanese government established a positive list system in 2006. Maximum residue levels (MRLs) have been... -
The Roles and Operations of Registered Conformity Assessment Body
As of August 2023, 99 organizations were registered as conformity assessment bodies by the Ministry of Health, Labour, and Welfare in accordance with Article 33 of the Food Sanitation Act. These registered organizations are authorized to conduct inspections of imported food as well as domestic expropriation inspections. In recent years, we have actively participated in a project to develop new test methods, aiming to enhance our contribution as a registered testing organization and to maintain... -
Analytical Methods for Residual Compositional Substances of Agricultural Chemicals, Feed Additives, and Veterinary Drugs in Foods
Pesticides, veterinary drugs, and feed additives (hereinafter referred to as "pesticides") can remain in foods when used in agricultural and livestock products. Since consuming a variety of foods every day can result in ingesting trace amounts of these pesticides, which may be harmful to health, risk management for residual pesticides in foods is necessary to prevent adverse effects. Based on the Food Sanitation Act, the Ministry of Health, Labour and Welfare (MHLW) has established maximum... -
Photodegradation of typical psychotropic drugs in the aquatic environment: a critical review
Continuous consumption combined with incomplete removal during wastewater treatment means residues of psychotropic drugs (PDs), including antidepressants, antipsychotics, antiepileptics and illicit drugs, are continuously entering the aquatic environment, where they have the potential to affect non-target organisms. Photochemical transformation is an important aspect to consider when evaluating the environmental persistence of PDs, particularly for those present in sunlit surface waters. This... -
State-of-the-art progress and prospect of metal-organic frameworks and composites for photoelectrochemical amino-drugs sensing
Unregulated discharge of antibiotics in waterbodies has posed a significant threat to the aquatic flora and fauna in post-pandemic times. This alarming situation has ascertained the need for suitable sensors to detect persistent antibiotic residues. In this context, functional hybrid materials centralized on reticular metal-organic frameworks (MOFs)/composites have been a research hot spot for photoelectrochemical host-guest recognition events over the past two decades. The unique amalgamation... -
Strategies for processing and valorization of ash gourd byproducts: A comprehensive review
Ash gourd (Benincasa hispida) is cultivated for its medicinal benefits, with processing enhancing its health properties and shelf life. The processing industries generate significant byproducts, with peel and seeds common across all methods, along with lime (from petha sweet production), brine wastewater (from fermented foods), and pulp from juice processing. This review focuses on peel, seeds, and lime wastewater, which contain valuable compounds like polyphenols, terpenoids, essential oils,... -
Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach
BACKGROUND: The human gut microbiota has a critical role in several aspects of host homeostasis, such as immune development, metabolism, nutrition, and defense against pathogens during life. It can be sensitive to xenobiotics including drugs, diet, or even environmental pollutants, especially heavy metals (HMs). The findings of some previous studies are heterogeneous due to the inclusion of various types of study (human, and animal studies) and wide exposures (phthalate, bisphenol A, HMS, etc.),... -
Microbes as Resources to Remove PPCPs and Improve Water Quality
The inadequate removal of pharmaceuticals and personal care products (PPCPs) by traditional wastewater treatment plants (WWTPs) poses a significant environmental and public health challenge. Residual PPCPs find their way into aquatic ecosystems, leading to bioaccumulation in aquatic biota, the dissemination of antibiotic resistance genes (ARGs), and contamination of both water sources and vegetables. These persistent pollutants can have negative effects on human health, ranging from antibiotic... -
The impact of aflatoxin B1 on animal health: Metabolic processes, detection methods, and preventive measures
Aflatoxin (AF) is a toxic metabolite produced by the fungus Aspergillus. The various subtypes of AFs include B1, B2, G1, G2, M1, and M2, with Aflatoxin B1 (AFB1) being the most toxic. These AFs are widespread in the environment, particularly in soil and food crops. The World Health Organization (WHO) has classified AFB1 as a highly potent natural Class 1A carcinogen. Excessive exposure to AFB1 can lead to poisoning in both humans and animals, posing substantial risks to food safety and livestock... -
Unraveling the nutritional potential of millet by-products through extraction of high value compounds for the development of novel food products
Millets are drought-resistant crops that generate significant amount of by-products (bran, husk, stalk etc.) during harvesting and processing. These by-products are storehouse of nutrients and high value compounds including polyphenols, dietary fiber, proteins etc. However, these by-products remain underutilized and generally discarded, burned or used as feedstock causing adverse impact on the environment and human health in addition to loss of valuable nutrients. Therefore, the valorization of... -
A comprehensive review of sustainable hydrogels from lignin for advanced wastewater solutions
Throughout the recent years, water bodies have been significantly contaminated via various industrial and pollution wastes posing threats to the living. To tackle the situation, Lignin-Based Hydrogels have appeared as a material with great potential for wastewater treatment. Biomass-derived polymers for wastewater treatment present a sustainable replacement to plastics based on petroleum owing to its biocompatibility, affordability, eco-friendliness and biodegradability. After cellulose the... -
Managing strategies of chemotherapy and radiotherapy-induced oral mucositis
Radiotherapy and chemotherapy are widely employed as primary non-surgical cancer treatments; however, their non-selective cytotoxicity often leads to adverse events such as oral mucositis (OM), particularly in head and neck cancer therapies. International guidelines provide recommendations for managing chemoradiotherapy-induced OM in various clinical contexts. Subsequently, emerging researches have introduced evidence supporting novel approaches or existing regimens for OM prevention and... -
Protein Based Hybrid Materials of Metal Phosphate Nanoflowers and Gels for Water Remediation: Perspectives and Prospects
Water pollution is a critical environmental issue affecting ecosystems and human health worldwide. Contaminants such as heavy metals, dyes, antibiotics, and microplastics enter water bodies from the disposals of industrial, agricultural, and domestic waste. The development of new and advanced technologies for addressing water remediation has turned out to be a dire need. Protein-inorganic hybrid materials have emerged as innovative solutions for water remediation, leveraging the unique... -
Factors influencing surimi gelling properties and natural additive-based gel fortification strategies: A review
Gelation and gel properties are crucial to surimi-based seafood products, and many factors significantly influence surimi gel quality. Although physical and chemical modifications can improve surimi gel performance, challenges such as high cost, difficulties in industrialization and environmental pollution pose significant barriers to their practicality. Natural additives offer a promising alternative by reinforcing and improving the characteristics of surimi gel through mechanisms such as... -
Environmental Impact of Xenobiotic Aromatic Compounds and Their Biodegradation Potential in Comamonas testosteroni
Xenobiotic aromatic compounds are the raw materials of necessities in modern life, such as plastics, pesticides, and antibiotics. To meet the global requirements, their production and consumption have continually increased, and thus, the vast amount of waste generated results in prominent environmental pollution. Fortunately, some microorganisms (e.g., Comamonas spp.) can specially use these pollutants as substrates for growth, allowing for the development of bioremediation technology to achieve... -
Environmental bioremediation of pharmaceutical residues: microbial processes and technological innovations: a review
The ubiquitous presence of pharmaceuticals and personal care products (PPCPs) in the environment has become a significant concern due to their persistence, bioaccumulation potential in biota, and diverse implications for human health and wildlife. This review provides an overview of the current state-of-the-art in environmental bioremediation techniques for reducing pharmaceutical residues, with a special emphasis on microbial physiological aspects. Numerous microorganisms, including algae,... -
Recent Advances in Enantiorecognition and Enantioseparation Techniques of Chiral Molecules in the Pharmaceutical Field
Enantioseparation and enantiorecognition are crucial in the pharmaceutical analysis of chiral substances, impacting safety, efficacy, and regulatory compliance. Enantioseparation refers to the process of separating enantiomers from a mixture, typically achieved through chromatography techniques like HPLC and SFC. In contrast, enantiorecognition involves the identification of enantiomers based on their interaction with a chiral selector without the need for separation. Recent advancements in... -
Insights and perspectives of chitosan-based hydrogels for the removal of heavy metals and dyes from wastewater
Water pollution has become an increasingly serious issue, necessitating the design and development of more effective wastewater treatment methods. Chitosan-based hydrogels, owing to their unique structural and chemical properties, have demonstrated high efficiency in removing contaminants. However, the application remains restricted by the scarcity of effective adsorption sites and limited environmental stability. This review summarizes recent advances in the production of chitosan-based... -
Research Progress on Using Modified Hydrogel Coatings as Marine Antifouling Materials
The adhesion of marine organisms to marine facilities negatively impacts human productivity. This phenomenon, known as marine fouling, constitutes a serious issue in the marine equipment industry. It increases resistance for ships and their structures, which, in turn, raises fuel consumption and reduces ship speed. To date, numerous antifouling strategies have been researched to combat marine biofouling. However, a multitude of these resources face long-term usability issues due to various... -
Drug protection against radiation-induced neurological injury: mechanisms and developments
In daily life, individuals are frequently exposed to various forms of radiation, which, when adhering to safety standards, typically result in relatively minor health effects. However, accidental exposure to radiation levels that exceed these safety standards can lead to significant health consequences. This study focuses on the analysis of radiation-induced damage to the nervous system and the mechanisms of pharmacological protection. The findings indicate that radiation can adversely affect... -
Advances in molecular networking technology for discovering emerging contaminants and transformation products
Emerging contaminants and their transformation products are widely distributed in the environment. These pollutants carry unknown risks owing to their persistence, migration, and toxicity. The wide variety and complex structures of these substances render them difficult to identify using only target analysis. Suspect screening analysis can identify more substances than target analysis in a single run. However, this analysis method is based on limited data and cannot meet the growing demand for... -
Cytotoxic surface contamination in hospitals: Current practices, challenges and perspectives
ObjectiveDespite significant advances in cancer treatment with targeted therapies and immunotherapies, cytotoxic chemotherapies are still extensively used. Potential cytotoxic contamination in preparing and administrating cytotoxics is still a major source of concern. Besides advanced protections including biological safety cabinets, work surface contamination needs to be continuously controlled to ensure that handling procedures and cleaning were appropriate. Contamination monitoring needs to... -
A critical review on the symbiotic effect of bacteria and microalgae on treatment of sewage with biofertilizer production
Wastes like sewage, kitchen and industrial are the major sources of environmental pollution and health hazards. Sewage contains 99.9% water and 0.1% solid waste including urinal waste and faecal matter alongwith large amounts of nitrate, nitrite, ammonium and phosphate ions. Sewage may also contain a variety of harmful contaminants like analgesics, antihypertensive drugs, antibiotics, dioxin, furans, polychlorinated biphenyls, chlorinated hydrocarbon pesticides, chlorine derivatives and... -
Development and application of hydrogels in pathogenic bacteria detection in foods
Hydrogels are 3D networks of water-swollen hydrophilic polymers. It possesses unique properties (e.g., carrying biorecognition elements and creating a micro-environment) that make it highly suitable for bacteria detection (e.g., expedited and effective bacteria detection) and mitigation of bacterial contamination in specific environments (e.g., food systems). This study first introduces the materials used to create hydrogels for bacteria detection and the mechanisms for detection. We also... -
Exposure to bioaerosol in the residential environment
The aim of review was to describe the knowledge about exposures to bacteria, fungi and viruses present in bioaerosol in residential environment in moderate climate condition, in connection with health effects in humans, their sources. The basis for the narrative literature review were peer-reviewed papers published between January 2000 and September 2023 in English and Polish, meeting the established criteria. Knowledge about fungi, bacteria and viruses harmful to humans that may be present in... -
Current and Potential Use of Biologically Active Compounds Derived from Cannabis sativa L. in the Treatment of Selected Diseases
Cannabis sativa L. contains numerous compounds with antioxidant and anti-inflammatory properties, including the flavonoids and the cannabinoids, particularly Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabinoids have an effect on the endocannabinoid system (ECS), a cellular communication network, and are, hence, widely studied for medical applications. Epidiolex^(®), a 99% pure oral CBD extract, has been approved by the FDA for the treatment of epilepsy. Nabiximols (Sativex) is an... -
Unlocking the Potential of Keratin: A Comprehensive Exploration from Extraction and Structural Properties to Cross-Disciplinary Applications
The rapid expansion of the livestock and poultry industry has led to a considerable increase in slaughter byproducts; however, exploring their potential applications still needs to be improved. These underutilized byproducts, which include nails, hides, skins, and bones, represent a significant loss of valuable biological resources. Among these materials, keratin has garnered considerable attention due to its unique properties as a natural biopolymer. Keratin exhibits outstanding mechanical... -
Laccase-based biocatalytic systems application in sustainable degradation of pharmaceutically active contaminants
The outflow of pharmaceutically active chemicals (PhACs) exerts a negative impact on biological systems even at extremely low concentrations. For instance, enormous threats to human and aquatic species have resulted from the widespread use of antibiotics in ecosystems, which stimulate the emergence and formation of antibiotic-resistant bacterial species and associated genes. Additionally, it is challenging to eliminate these PhACs by employing conventional physicochemical water treatment... -
Efficacy and safety of QingReJieDu therapy in preventing acute radiation esophagitis: A systematic review and meta-analysis
CONCLUSION: Our results indicate that QRJD therapy has a significant preventive effect on ARE in clinical practice. However, it is important to note that these findings should be confirmed through more rigorously designed, multicenter, large-sample, and large-scale randomized controlled trials. -
Pints of the past, flavours for the future
The recreation of historic beverages is possible via contemporary fermentations carried out with microbes revived form the past. Advanced molecular techniques have recently provided opportunities to investigate historic samples, such as those from beer found in shipwrecks, and provide data on their character as well as identifying differences with contemporary products. In some cases, isolates of yeasts and bacteria create the possibility for authentic recreations of fermented beverages that can... -
Exosomes derived stem cells as a modern therapeutic approach for skin rejuvenation and hair regrowth
BACKGROUND: The skin covers the surface of the body and acts as the first defense barrier against environmental damage. Exposure of the skin to environmental physical and chemical factors such as mechanical injuries, UV rays, air pollution, chemicals, etc. Leads to numerous damages to skin cells such as fibroblasts, keratinocytes, melanocytes, etc. The harmful effects of environmental factors on skin cells could lead to various skin diseases, chronic wounds, wrinkles, and skin aging. Hair is an... -
Comprehensive Advancements in Hydrogel, and Its Application in Microalgae Cultivation and Wastewater Treatment
Microalgae are recognized as a sustainable resource to produce biofertilizers, biofuels, and pigments, with the added benefits of environmental sustainability, such as carbon sequestration and pollutant removal. However, traditional cultivation methods face challenges like low biomass productivity and high operational costs. This review focuses on the innovative use of hydrogels as a medium for microalgae cultivation, which addresses these challenges by enhancing nutrient permeability, light... -
The art of biodegradable polymer design for the treatments against osteomyelitis
Osteomyelitis arises from the incomplete treatment of the external wounds in the healing process, while bacterial infections persist within the bone marrow, leading to abscess formation. Osteomyelitis treatments generally involve three main aspects: rapid bactericidal action, sustained bacteriostasis, and induction of bone regeneration. However, current treatment methods, which often combine surgical debridement with long-term high-dose intravenous antibiotic administration or poly(methyl... -
From flavor to function: A review of fermented fruit drinks, their microbial profiles and health benefits
Fermented fruit drinks (FFDs) are gaining popularity among consumers for their unique flavors and potential health benefits. This review provides a systematic assessment of the flavor components in FFDs and explores the metabolic pathways for their formation. We examine the interactions between the structure of microbial communities and the development of these flavor components, highlighting the role of microorganisms in shaping the unique taste of FFDs. Additionally, we discuss the potential... -
Indoor bioaerosols and asthma: Overview, implications, and mitigation strategies
Aerosolized particles with a biological origin are called bioaerosols. Bioaerosols from plants, animals, fungi, bacteria, and viruses are an important class of environmental exposures that are clinically relevant to asthma. However, there are important differences in the pathways by which various bioaerosols affect asthma. Additionally, differences in individual susceptibility to different bioaerosols affect exposure reduction and mitigation strategies. Strategies to reduce exposures to... -
Selected emerging contaminants in water: Global occurrence, existing treatment technologies, regulations and associated risk
Emerging contaminants (ECs) in aquatic environments have recently attracted the attention of researchers due to their ubiquitous occurrence and the potential risk they may pose to life. While advance analytical methods have improved global reporting in water matrices, additional information is needed to compile data on their occurrence, existing legislation, treatment technologies and associated human health risks. Therefore, the present study provides an overview of the occurrence of selected... -
Occurrence of selected Covid-19 drugs in surface water resources: a review of their sources, pathways, receptors, fate, ecotoxicity, and possible interactions with heavy metals in aquatic ecosystems
The outbreak of the coronavirus disease 2019 (Covid-19) led to the high consumption of antibiotics such as azithromycin as well as corticosteroids such as prednisone, prednisolone, and dexamethasone used to treat the disease. Seemingly, the concentrations of these four Covid-19 drugs increased in wastewater effluents and surface water resources. This is due to the failure of traditional wastewater treatment facilities (WWTFs) to eliminate pharmaceuticals from wastewater. Therefore, the objective... -
The Influence of Environmental Exposure to Xenoestrogens on the Risk of Cancer Development
Xenoestrogens (XEs) are a group of exogenous substances that may interfere with the functioning of the endocrine system. They may mimic the function of estrogens, and their sources are plants, water or dust, plastic, chemical agents, and some drugs. Thus, people are highly exposed to their actions. Together with the development of industry, the number of XEs in our environment increases. They interact directly with estrogen receptors, disrupting the transmission of cellular signals. It is proven... -
Veterinary tetracycline residues: Environmental occurrence, ecotoxicity, and degradation mechanism
Tetracycline has been widely used in the intensive livestock and poultry breeding industry to prevent and treat infectious diseases or promote animal growth. Usually, about 40.0-90.0% of tetracycline is excreted in the form of original drugs or metabolites and finally enters the surrounding water and soil, causing a series of eco-toxic effects. In this review, the toxic effects on plants, soil animals, and microorganisms are systematically reviewed. The migration and degradation mechanisms of... -
An investigative review of the expanded capabilities of thermal/optical techniques for measuring carbonaceous aerosols and beyond
Carbonaceous aerosols primarily comprise organic carbon (OC) and black carbon (BC). Thermal-optical analysis (TOA) is the most commonly used method for separating carbonaceous aerosols into OC and EC (BC is referred to as elemental carbon EC, in this method). Advances in hardware design and algorithms have expanded the capabilities of TOA beyond just distinguishing OC and EC. However, a comprehensive understanding of the enhanced functionality of TOA is still lacking. This study provides the... -
Airborne DNA: State of the art - Established methods and missing pieces in the molecular genetic detection of airborne microorganisms, viruses and plant particles
Bioaerosol is composed of different particles, originating from organisms, or their fragments with different origin, shape, and size. Sampling, analysing, identification and describing this airborne diversity has been carried out for over 100 years, and more recently the use of molecular genetic tools has been implemented. However, up to now there are no established protocols or standards for detecting airborne diversity of bacteria, fungi, viruses, pollen, and plant particles. In this review we... -
The definition of chemical contaminants in food: Ambiguity and consequences
Consumers may be exposed via foods to a diverse range of substances that could be considered as contaminants. However, it is not always straightforward to understand the definition of a 'contaminant'. The present review evaluates how various categories of food-relevant substances are considered in terms of being 'contaminants'. To this end these categories of food borne constituents are evaluated against the various criteria encountered in the available definitions of a food contaminant,... -
Revolutionizing dairy waste: emerging solutions in conjunction with microbial engineering
The dairy industry is grappling with significant challenges in managing effluent due to environmental concerns and stringent regulatory demands, necessitating innovative solutions. The paper investigates how microbial engineering is transforming the treatment of dairy wastewater, offering advanced methods to minimize environmental impact and enhance sustainability. It delves into the current challenges faced by the dairy industry, such as regulatory compliance and the limitations of traditional... -
Insights into the efficiencies of different biological treatment systems for pharmaceuticals removal: A review
This review presents a comprehensive analysis of current research on biological treatment processes for removing pharmaceutical compounds (PhCs) from wastewater. Unlike previous studies on this topic, our study specifically delves into the effectiveness and drawbacks of various treatment approaches such as traditional wastewater treatment facilities (WWTP), membrane bioreactors (MBRs), constructed wetlands (CW), and moving bed biofilm reactors (MBBR). Through the examination and synthesis of... -
Polysaccharide-based biopolymeric magnetic hydrogels for remediation of antibiotics from aqueous solution
Polysaccharide-based biopolymeric magnetic hydrogels have garnered significant attention as effective materials for wastewater treatment due to their high adsorption capacity and environmentally friendly nature. This review examines recent advancements in the development of biopolymeric magnetic hydrogels derived from polysaccharides such as cellulose, chitosan, alginate, carrageenan, starch, and gums, with a focus on their application in removing antibiotics from contaminated water as it not... -
From prescription to pollution: The ecological consequences of NSAIDs in aquatic ecosystems
Nonsteroidal anti-inflammatory drugs are widely utilised to alleviate pain and reduce inflammation in both human and veterinary medicine. Despite their therapeutic benefits, NSAIDs pose environmental concerns due to their possible ecotoxicity. NSAIDs can enter aquatic ecosystems through wastewater discharge as it is very difficult to extract NSAIDs by conventional wastewater treatment, thus affecting aquatic life. These drugs induce cytotoxic and genotoxic effects, affect the functioning of... -
Applications of artificial intelligence for chemical analysis and monitoring of pharmaceutical and personal care products in water and wastewater: A review
Specifying and interpreting the occurrence of emerging pollutants is essential for assessing treatment processes and plants, conducting wastewater-based epidemiology, and advancing environmental toxicology research. In recent years, artificial intelligence (AI) has been increasingly applied to enhance chemical analysis and monitoring of contaminants in environmental water and wastewater. However, their specific roles targeting pharmaceuticals and personal care products (PPCPs) have not been... -
Removal and elimination of pharmaceuticals in water using zeolites in diverse adsorption processes and catalytic advanced oxidation technologies-a critical review
Water pollution by pharmaceuticals is a current worrying environmental problem. Adsorption and catalytic processes using zeolites have been employed in several studies to remove/degrade pharmaceuticals from water. The interest of researchers in these two strategies based on the utilization of zeolites (i.e., adsorption and advanced oxidation technologies, AOT) is continuously growing. Then, this work presents a literature review, considering the origin of the zeolites (natural vs. synthetic) and... -
Green technologies for extracting plant waste functional ingredients and new food formulation: A review
Nowadays, there is a growing interest in food waste recovery by both consumers and companies. Food waste of plant origin is a source of bioactive compounds, such as phenolic acids, anthocyanins, flavonoids, phytosterols, carotenoids, and tocopherols, with well-known antioxidant, anti-glycemic, and antimicrobial properties. The use of green and sustainable technologies to recover bioactive compounds from food waste is a possible solution to valorize waste following the principles of green... -
Bioaerogels from biomass waste: An alternative sustainable approach for wastewater treatment
The generation of municipal solid waste is projected to increase from 2.1 billion tonnes in 2023 to 3.8 billion tonnes by 2050. In 2020, the direct global cost of managing this waste was approximately USD 252 billion. When considering additional hidden costs-such as those arising from pollution, adverse health effects, and climate change due to inadequate waste disposal-the total cost escalates to USD 361 billion. Without significant improvements in waste management practices, this figure could... -
Pharmaceuticals in urban streams: A review of their detection and effects in the ecosystem
The presence of pharmaceuticals in urban freshwater has been considered an emerging issue. Although rivers are better studied, the streams crossing the cities, which are prone to higher concentrations of pharmaceuticals, and with a higher potential to affect animals, plant and human health, were never specifically addressed in a review. Thus, here we performed a literature review on the existing pharmaceutical contamination and impacts of these compounds in the urban stream ecosystems. To... -
Starch-based bio-membrane for water purification, biomedical waste, and environmental remediation
This review article explores the utilization of starch-based materials as smart materials for the removal of dyes and heavy metals from wastewater, highlighting their cost-effectiveness, biodegradability, and biocompatibility. It addresses the critical need for clean water, emphasizing the contamination caused by industrial activities, such as printing, textile, cosmetic, and leather tanning industries. Starch and its derivatives demonstrate significant potential in water purification...
